Last reviewed: October 5, 2026
Aβ–Tau Inflection and Resilience Spatial Atlas
Lundbeck, VIB-KU Leuven, Netherlands Brain Bank, and collaborators
Data typespatial transcriptomics and single-nucleus RNA-seq
Specieshuman
Sample countSuperior frontal cortex from octogenarians with and without dementia and cognitively intact centenarians
Technology10x Visium, Xenium, snRNA-seq, spatial domain analysis
Disease contextAlzheimer's disease, Cognitive resilience, Exceptional longevity, Control
Notes
Maps early inflammatory and late antigen-presenting plaque-induced gene programs across six spatial pathology domains. Raw human sequencing data are controlled-access through EGA (Visium EGAD50000002431; snRNA-seq EGAD50000002432), so this is not an unrestricted download.
Primary publication
Human microglial transitions at the Aβ–tau inflection point associate with divergent pathways to dementia and resilience (2026)
Sources
Last reviewed: October 5, 2026