Index

Target × Disease Matrix

Cells show evidence labels for targets with documented links to each disease. Labels reflect the target's overall evidence base when it links to that disease. Click any target symbol to view the full entry.

Filter by Evidence Label

Target	AD Alzheimer's disease	ALS Amyotrophic lateral sclerosis	Aging Brain aging	FTD Frontotemporal dementia	LBD Lewy body dementia	MS Multiple sclerosis	NHD Nasu-Hakola disease	PD Parkinson's disease	TBI Traumatic brain injury
ABI3	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model	—	—	—	—	—	—	—	—
APOE	HG human genetics HT human tissue sc single-cell RNA-seq Pr proteomics AM animal model CP clinical program	—	HG human genetics HT human tissue sc single-cell RNA-seq Pr proteomics AM animal model CP clinical program	HG human genetics HT human tissue sc single-cell RNA-seq Pr proteomics AM animal model CP clinical program	HG human genetics HT human tissue sc single-cell RNA-seq Pr proteomics AM animal model CP clinical program	—	—	—	—
AXL	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	—	—	—	—	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	—
BIN1	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CM computational model	—	—	—	—	—	—	—	—
C1QA	HT human tissue sc single-cell RNA-seq ST spatial transcriptomics AM animal model IV in vitro assay	HT human tissue sc single-cell RNA-seq ST spatial transcriptomics AM animal model IV in vitro assay	HT human tissue sc single-cell RNA-seq ST spatial transcriptomics AM animal model IV in vitro assay	—	—	HT human tissue sc single-cell RNA-seq ST spatial transcriptomics AM animal model IV in vitro assay	—	HT human tissue sc single-cell RNA-seq ST spatial transcriptomics AM animal model IV in vitro assay	—
C3	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	—	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	—	—	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	—	—	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay
CD33	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay CP clinical program	—	—	—	—	—	—	—	—
CLEC7A	HT human tissue sc single-cell RNA-seq ST spatial transcriptomics AM animal model IV in vitro assay	HT human tissue sc single-cell RNA-seq ST spatial transcriptomics AM animal model IV in vitro assay	—	—	—	HT human tissue sc single-cell RNA-seq ST spatial transcriptomics AM animal model IV in vitro assay	—	—	—
CSF1R	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	—	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	—	—	—
CST7	HT human tissue sc single-cell RNA-seq ST spatial transcriptomics AM animal model	HT human tissue sc single-cell RNA-seq ST spatial transcriptomics AM animal model	—	—	—	HT human tissue sc single-cell RNA-seq ST spatial transcriptomics AM animal model	—	—	—
CX3CR1	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	—	—	—	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	—	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	—
GPNMB	HT human tissue sc single-cell RNA-seq Pr proteomics AM animal model	—	—	HT human tissue sc single-cell RNA-seq Pr proteomics AM animal model	—	—	—	HT human tissue sc single-cell RNA-seq Pr proteomics AM animal model	—
GRN	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	—	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	—	—	—	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	—
HEXB	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model	—	—	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model	—	—	—	—	—
INPP5D	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	—	—	—	—	—	—	—	—
ITGAM	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model	—	—	—	—	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model	—	—	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model
LILRB2	HG human genetics HT human tissue sc single-cell RNA-seq IV in vitro assay	—	—	—	—	—	—	—	—
LRRK2	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	—	—	—	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	—	—	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	—
MERTK	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	—	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	—	—	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	—	—	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay
MS4A4A	HG human genetics HT human tissue sc single-cell RNA-seq IV in vitro assay	—	—	—	—	—	—	—	—
MS4A6A	HG human genetics HT human tissue sc single-cell RNA-seq	—	—	—	—	—	—	—	—
NLRP3	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay CP clinical program	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay CP clinical program	—	—	—	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay CP clinical program	—	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay CP clinical program	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay CP clinical program
P2RY12	HT human tissue sc single-cell RNA-seq AM animal model	—	HT human tissue sc single-cell RNA-seq AM animal model	—	—	HT human tissue sc single-cell RNA-seq AM animal model	—	—	HT human tissue sc single-cell RNA-seq AM animal model
PLCG2	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	—	—	—	—	—	—	—	—
SIRPA	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	—	HT human tissue sc single-cell RNA-seq AM animal model IV in vitro assay	—	—	—	—	—	—
SPI1	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CM computational model	—	—	—	—	—	—	—	—
SPP1	HT human tissue sc single-cell RNA-seq ST spatial transcriptomics Pr proteomics AM animal model	HT human tissue sc single-cell RNA-seq ST spatial transcriptomics Pr proteomics AM animal model	—	—	—	HT human tissue sc single-cell RNA-seq ST spatial transcriptomics Pr proteomics AM animal model	—	HT human tissue sc single-cell RNA-seq ST spatial transcriptomics Pr proteomics AM animal model	—
TMEM119	HT human tissue sc single-cell RNA-seq AM animal model	—	HT human tissue sc single-cell RNA-seq AM animal model	—	—	HT human tissue sc single-cell RNA-seq AM animal model	—	—	HT human tissue sc single-cell RNA-seq AM animal model
TREM2	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	—	—	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	—	—	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CP clinical program	—
TYROBP	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CM computational model	—	—	—	—	—	HG human genetics HT human tissue sc single-cell RNA-seq AM animal model CM computational model	—	—

Disease Key

ADAlzheimer's disease

ALSAmyotrophic lateral sclerosis

AgingBrain aging

FTDFrontotemporal dementia

LBDLewy body dementia

MSMultiple sclerosis

NHDNasu-Hakola disease

PDParkinson's disease

TBITraumatic brain injury