BIN1
Bridging integrator 1 (Amphiphysin 2)
Also known as: BIN1, AMPH2, SH3P9
Biology & Mechanism
BIN1 is the second-most significant genetic risk locus for late-onset Alzheimer's disease after APOE. BIN1 encodes amphiphysin 2, involved in membrane remodeling, endocytosis, and actin regulation. In microglia, BIN1 modulates endocytic trafficking. BIN1 also influences tau pathology; it interacts with tau and may regulate tau propagation. BIN1 expression is altered in AD brain tissue.
Open Questions
- —Is the BIN1 AD risk effect primarily mediated through microglia or neurons?
- —Does BIN1 modulate tau propagation through extracellular vesicles or direct cell-to-cell contact?
- —Can BIN1 endocytic function be targeted to reduce tau pathology?
Sources
- Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease (2013)
Last reviewed: June 1, 2026