Last reviewed: October 5, 2026
Cross-pathology Microglia Taxonomy
University Medical Center Freiburg and international collaborators
Data typesingle-nucleus RNA-seq, spatial transcriptomics, imaging mass cytometry
Specieshuman, mouse
Sample countMore than 1 million CNS cells across over 30 conditions; 212 human samples and 245 mouse samples
Technology10x Genomics snRNA-seq, CosMx spatial transcriptomics, imaging mass cytometry
Disease contextNeurodegeneration, Neuroinflammation, Brain tumors, Infection, Development, Control
Notes
A disease- and species-spanning reference that organizes CNS myeloid cells into 27 superclusters and 192 clusters with spatial context. Human raw reads require EGA authorization; processed Seurat objects and reproducible figure code are public on Zenodo, and mouse reads are public in GEO.
Primary publication
A transcriptomic microglia taxonomy across mouse and human pathologies (2026)
Sources
Last reviewed: October 5, 2026