Last reviewed: June 3, 2026
Mouse Disease-Associated Microglia (DAM) Database
Amit Lab (Weizmann Institute)
Data typesingle-cell RNA-seq
Speciesmouse
Sample countMultiple 5XFAD and WT mice
TechnologyMARS-seq
Disease contextAlzheimer's disease
Notes
The foundational 2017 dataset establishing the concept of Disease-Associated Microglia (DAM). Contains the scRNA-seq mapping of homeostatic microglia transitioning into the TREM2-dependent effector state during Alzheimer's pathogenesis.
Primary publication
A unique microglia type associated with restricting development of Alzheimer's disease (2017)
Last reviewed: June 3, 2026