Last reviewed: October 5, 2026
HuMicA: Human Microglia Atlas
Vall d'Hebron Research Institute and collaborators
Data typesingle-cell RNA-seq, single-nucleus RNA-seq
Specieshuman
Sample count90,716 cells/nuclei from 241 samples across 19 public datasets
Technologysingle-cell RNA-seq, single-nucleus RNA-seq, Seurat integration, RNAscope validation
Disease contextAlzheimer's disease, Multiple sclerosis, Lewy body disease, Epilepsy, Autism spectrum disorder, COVID-19, Control
Notes
Cross-disease integration resolving eight microglial populations and one border-associated macrophage population. HuMicA is an integrated secondary atlas; batch, tissue-state, brain-region, and source-study effects remain important when reusing its state annotations.
Primary publication
The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions (2025)
Last reviewed: October 5, 2026