Last reviewed: October 5, 2026
Human Myeloid Aging and Alzheimer's Atlas
Icahn School of Medicine at Mount Sinai, NIH, and AMP-AD collaborators
Data typesingle-cell and single-nucleus RNA-seq with spatial validation
Specieshuman
Sample count832,505 myeloid cells from prefrontal cortex across 1,607 donors
TechnologyscRNA-seq, snRNA-seq, CITE-seq, Xenium spatial transcriptomics, pseudotime
Disease contextAlzheimer's disease, Brain aging, Control
Notes
Large human myeloid reference resolving six subclasses and 13 subtypes. A GPNMB-high microglial subtype expands with AD pathology and is linked to MITF and TREM2-dependent biology. Access uses the AD Knowledge Portal and may require an account and data-use agreement.
Primary publication
Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer's disease (2026)
Sources
Last reviewed: October 5, 2026