Last reviewed: October 5, 2026
Neurovascular–Microglia Disease Repository
Karolinska Institutet and international collaborators
Data typesingle-cell RNA-seq and spatial transcriptomics
Speciesmouse
Sample countMore than 250,000 vascular and microglial cells across disease stages
TechnologyscRNA-seq, spatial transcriptomics, immunofluorescence, electron microscopy
Disease contextAlzheimer's disease, CADASIL, Traumatic brain injury, Control
Notes
Cross-condition resource designed to compare vascular and microglial responses. Microglial programs were disease-specific, with convergence between late-stage TBI and AD. Data are split across GEO accessions GSE318960, GSE300113, and GSE327284.
Primary publication
Heterogenous microglial reactivity contrasts with stable vascular transcriptional programs in mouse models of Alzheimer's, CADASIL, and Traumatic Brain Injury (2026)
Sources
Last reviewed: October 5, 2026