Last reviewed: June 2, 2026
Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD)
Allen Institute, UW Medicine, Kaiser Permanente Washington
Data typesingle-nucleus RNA-seq, ATAC-seq, spatial transcriptomics, multiplex FISH
Specieshuman
Sample count135 brains across a continuous spectrum of AD pathology
Technology10x Genomics scRNA-seq, MERFISH, snATAC-seq
Disease contextAlzheimer's disease, Control, Brain aging
Notes
The SEA-AD atlas precisely maps the single-cell trajectory of Alzheimer's disease across all six Braak stages. Features a robust microglial sub-clustering showing the continuum of microglial states transitioning from homeostatic to disease-associated phenotypes along the cascade.
Primary publication
Integrated multidimensional single-cell atlas of the human Alzheimer's disease brain (2024)
Sources
- SEA-AD Portal · Link
Last reviewed: June 2, 2026