TMEM119 marks a subset of microglia for deep brain stimulation circuit mapping

Abstract summary

Identified TMEM119 as a specific marker of homeostatic microglia in both mice and humans. Created TMEM119-GFP reporter mice and showed that TMEM119 expression is lost in reactive microglia. Demonstrated TMEM119's utility as a pan-microglial homeostatic marker for isolation and study.

Evidence labels

Therapeutic relevance

TMEM119 established as homeostatic microglial marker and potential readout for microglial state perturbation in therapeutic studies.