Last reviewed: June 1, 2026
2021Brain, Behavior and Immunity
INPP5D is an Alzheimer's disease risk gene implicated in microglial phagocytosis
Butler CA, et al.
Abstract summary
Characterized INPP5D (SHIP1) expression and function in human and mouse microglia. INPP5D is a phosphoinositide phosphatase that negatively regulates TREM2 signaling and phagocytosis. AD-associated INPP5D variants are associated with increased expression, suggesting that INPP5D limits microglial protective function. INPP5D inhibition enhances microglial amyloid clearance.
Evidence labels
human geneticshuman tissueanimal model
Diseases
- Alzheimer's disease
Species
human, mouse
Methods
RNA-seq, flow cytometry, pharmacology
Therapeutic relevance
INPP5D inhibition is a potential strategy to enhance TREM2-dependent microglial function in Alzheimer's disease.
Last reviewed: June 1, 2026