Defining microglial identity in the mouse brain using a combined transcriptomic and proteomics approach

Abstract summary

Established a comprehensive transcriptomic and proteomic signature distinguishing microglia from other brain cells and peripheral macrophages. Identified TMEM119, P2RY12, and SALL1 as specific microglial homeostatic markers. Showed that these markers are lost in disease states, establishing a molecular definition of microglial identity.

Evidence labels

Therapeutic relevance

Provided the molecular toolkit for distinguishing microglial states, foundational for biomarker and target development.