LRRK2 is expressed in microglia and differentially regulates microglial pro- and anti-inflammatory responses

Abstract summary

Demonstrated that LRRK2 is expressed in microglia and regulates cytokine production and microglial inflammatory responses. LRRK2 G2019S mutant microglia show exaggerated pro-inflammatory responses. LRRK2 kinase inhibition attenuates microglial activation. Established microglia as a key cellular context for LRRK2 function in PD.

Evidence labels

Therapeutic relevance

Microglia are a key cellular target of LRRK2 kinase inhibitors beyond dopaminergic neurons.