Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease

Abstract summary

Applied spatial transcriptomics to post-mortem AD brain tissue to map the spatial distribution of microglial states relative to pathological lesions. Identified enrichment of TREM2+ and SPP1+ microglial sub-populations around amyloid plaques and neurofibrillary tangles. Provided spatial context for disease-associated microglial states.

Evidence labels

Therapeutic relevance

Spatial mapping of microglial states around pathological lesions defines where therapeutic microglial modulation would be most needed.