Single-cell analysis of human microglia reveals neuropathology-associated reactivity during Alzheimer's disease progression

Abstract summary

Single-cell RNA-seq profiling of mouse microglia across multiple developmental stages and pathological contexts. Revealed significant microglial heterogeneity, including distinct proliferative, homeostatic, and disease-associated subpopulations. Homeostatic markers P2RY12, CX3CR1, and TMEM119 decline in disease-associated states.

Evidence labels

Therapeutic relevance

Defines homeostatic microglial markers and their loss in disease states, providing target context for microglial state monitoring.