Last reviewed: June 1, 2026
2011Nature Genetics
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, et al.
Abstract summary
GWAS meta-analysis identifying MS4A6A/MS4A4E, CD33, EPHA1, and ABCA7 as new Alzheimer's disease susceptibility loci. Companion to Naj et al. 2011. MS4A6A and MS4A4A are expressed in microglia and regulate TREM2 surface expression. CD33 is an inhibitory receptor limiting microglial amyloid clearance.
Evidence labels
human genetics
Diseases
- Alzheimer's disease
Species
human
Methods
genome-wide association study, meta-analysis
Therapeutic relevance
Identified MS4A and CD33 as microglial genetic risk factors; both are targets of therapeutic programs aimed at enhancing microglial function in AD.
Last reviewed: June 1, 2026