Last reviewed: June 1, 2026
2017Cell
Disease-associated microglia: a universal response to neurological insults
Keren-Shaul H, Spinrad A, Weiner A, Matcovitch-Natan O, Dvir-Szternfeld R, Ulland TK, et al.
Abstract summary
Identified and characterized the disease-associated microglia (DAM) transcriptional state using single-cell RNA-seq in mouse AD models. DAM signature includes upregulation of TREM2, SPP1, CST7, CLEC7A, and GPNMB while downregulating homeostatic markers P2RY12 and CX3CR1. TREM2 was shown to be required for the full DAM transition.
Evidence labels
single-cell RNA-seqanimal model
Diseases
- Alzheimer's disease
Species
mouse
Methods
single-cell RNA-seq, flow cytometry
Therapeutic relevance
Defined the DAM state as a key reference framework for microglial drug target identification.
Last reviewed: June 1, 2026