Last reviewed: June 1, 2026
2017Immunity
APOE and TREM2 regulate the disease-associated microglial response in Alzheimer's disease
Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, et al.
Abstract summary
Identified a microglial state regulatory axis in which TREM2 signaling via APOE drives the transition from homeostatic to disease-associated microglia (DAM). Blocking APOE or TREM2 impairs the DAM response. This work established TREM2-APOE as the central signaling axis for disease-associated microglial activation.
Evidence labels
single-cell RNA-seqanimal modelhuman tissue
Diseases
- Alzheimer's disease
- Amyotrophic lateral sclerosis
Species
mouse, human
Methods
single-cell RNA-seq, flow cytometry, mouse genetics
Therapeutic relevance
Defines TREM2-APOE axis as mechanistic basis for disease-associated microglial states across multiple neurodegenerative diseases.
Last reviewed: June 1, 2026