Spatial transcriptomics reveals unique molecular fingerprints of human microglia

Abstract summary

Used spatial transcriptomics and single-cell sequencing to map human microglia subpopulations across different brain regions. Found region-specific microglial transcriptional identities in human tissue. This study resolved the heterogeneity of human microglia beyond what was observable with bulk sequencing approaches.

Evidence labels

Therapeutic relevance

Region-specific microglial identities may explain differential vulnerability of brain regions in neurodegeneration and inform targeted therapies.