Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

Abstract summary

Showed that progranulin-deficient microglia display exaggerated inflammatory responses and impaired phagocytosis. In the context of toxin-induced neuronal injury, GRN knockout mice show greater neuroinflammation and neurodegeneration. Progranulin regulates lysosomal function and cytokine production in microglia.

Evidence labels

Therapeutic relevance

GRN replacement therapy targets microglial lysosomal dysfunction and neuroinflammation in FTD.