Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Abstract summary

Seminal two-photon imaging study demonstrating that 'resting' microglia are in fact highly active, continuously extending and retracting their processes to survey the brain parenchyma. Established that microglia scan their local environment approximately every few hours. This work redefined the concept of microglial quiescence.

Evidence labels

Therapeutic relevance

Established the surveillance paradigm for microglial function, foundational for interpreting microglial dynamics in disease.