Microglia Biology: One Century of Evolving Concepts

Abstract summary

Comprehensive review of microglial function in CNS development, homeostasis, and disease. Covered microglial ontogeny, transcriptional control, spatial heterogeneity, and diverse roles in neurodegenerative and neuroinflammatory conditions. Highlighted key unanswered questions and therapeutic opportunities.

Evidence labels

Therapeutic relevance

Synthesizes the rationale for targeting microglia across multiple neurological conditions.