MS4A4A: a novel cell surface marker for M2 macrophages and plasma cells

Abstract summary

Characterized MS4A4A expression in macrophages and microglia. Showed that MS4A4A is induced in alternatively activated (M2) macrophages and is regulated by IL-4 signaling. MS4A4A is a Siglec-3 (CD33) binding partner and modulates microglial surface receptor dynamics. Relevant to the MS4A gene cluster implicated in Alzheimer's disease GWAS.

Evidence labels

Therapeutic relevance

MS4A4A as part of the AD-associated MS4A locus may modulate microglial TREM2 surface levels and amyloid response.