How neuroinflammation contributes to neurodegeneration

Abstract summary

Critical review challenging prevalent oversimplifications of microglial biology. Argued against the binary M1/M2 polarization framework and emphasized the complexity of microglial states. Emphasized that homeostatic microglia are highly specialized and cannot be reduced to peripheral macrophage analogies.

Evidence labels

Therapeutic relevance

Highlighted need for precise characterization of microglial states before therapeutic targeting, influencing field methodology.