Colony stimulating factor 1 receptor (CSF1R) signaling mediates macrophage and microglia differentiation

Abstract summary

Comprehensive review of CSF1R biology, covering its role as the receptor for both CSF1 (M-CSF) and IL-34. Reviewed CSF1R signaling in macrophage development, survival, and proliferation, with specific focus on microglia. Highlighted CSF1R as the non-redundant survival receptor for the microglial lineage from development through adulthood.

Evidence labels

Therapeutic relevance

Establishes CSF1R as the central regulator of microglial survival, the rationale for CSF1R inhibitor programs targeting neuroinflammation.