TREM2 sustains microglial expansion and plaque containment in Alzheimer's disease

Abstract summary

Demonstrated that TREM2 deficiency impairs microglial proliferation and metabolic fitness in response to amyloid plaques. TREM2-deficient microglia fail to surround and compact plaques, leading to increased plaque-associated neuritic dystrophy. TREM2 was shown to drive the transition from homeostatic to disease-associated microglial states.

Evidence labels

Therapeutic relevance

Established that TREM2 activity supports protective microglial barrier function around amyloid plaques, the mechanistic basis for TREM2 agonist approaches.