Last reviewed: June 1, 2026
2016Neuron
TREM2 is a receptor that senses amyloid-beta plaques and lipid bilayers
Yeh FL, Wang Y, Tom I, et al.
Abstract summary
Showed that TREM2 binds to ApoE and other lipoproteins as well as amyloid-beta plaques. TREM2 engagement with lipid-associated ligands promotes microglial migration toward and clustering around amyloid plaques. This ligand promiscuity places TREM2 at the interface of lipid sensing and amyloid clearance.
Evidence labels
human tissuein vitro assayanimal model
Diseases
- Alzheimer's disease
Species
human, mouse
Methods
binding assays, microscopy, flow cytometry
Therapeutic relevance
Identifies lipid-associated lipoprotein binding as a key TREM2 activation mechanism relevant to therapeutic agonist design.
Last reviewed: June 1, 2026