Single-cell multi-region dissection of Alzheimer's disease

Abstract summary

Large single-cell RNA-seq study of AD brain tissue across multiple regions. Identified a human AD microglial state (HAM) distinct from mouse DAM, enriched for APOE, SPP1, and CHI3L1. Showed that TREM2 loss-of-function reduces microglial response to amyloid pathology in humans. Cross-disease comparison with other neurodegenerative conditions.

Evidence labels

Therapeutic relevance

Identifies human AD microglial states as distinct from mouse models, with implications for target validation and preclinical translation.