Last reviewed: June 2, 2026

ROSMAP (Religious Orders Study and Memory and Aging Project)

Rush Alzheimer's Disease Center (RADC)

Data typebulk RNA-seq, single-nucleus RNA-seq, proteomics, whole genome sequencing, DNA methylation

Specieshuman

Sample countOver ~3,500 older persons, large subset with paired clinical, molecular, and pathologic data

TechnologyIllumina RNA-seq, 10x Genomics snRNA-seq, TMT Proteomics, Illumina WGS

Disease contextAlzheimer's disease, Mild Cognitive Impairment, Brain aging, Control

Notes

ROSMAP is a longitudinal clinical-pathologic cohort study. It is heavily utilized in microglial computational biology because of the massive statistical power linking longitudinal cognitive scores to post-mortem multi-omics.

Targets covered

TREM2 CD33 CR1 ABCA7 BIN1 PICALM APOE MS4A4A

Primary publication

The Religious Orders Study and the Rush Memory and Aging Project (2012)

Access dataset

Sources

Synapse ROSMAP Portal · Link

Last reviewed: June 2, 2026