Microglia in health and disease

Abstract summary

Comprehensive review of microglial biology covering origin, homeostasis, transcriptional identity, and disease states. Reviewed evidence for microglial involvement in Alzheimer's disease, ALS, MS, and other CNS disorders. Synthesized genetic and functional evidence for TREM2, DAP12/TYROBP, CX3CR1, and other core microglial genes.

Evidence labels

Therapeutic relevance

Comprehensive framework for understanding microglia as therapeutic targets across neurological disease.