Last reviewed: June 1, 2026
2018Cell
The microglia universe
Deczkowska A, Keren-Shaul H, Weiner A, Colonna M, Schwartz M, Amit I
Abstract summary
Comprehensive review of microglial states including homeostatic microglia, disease-associated microglia (DAM), and other reactive states across neurological diseases. Synthesized single-cell transcriptomic data to propose a unified framework of microglial reactivity. Highlighted DAM as a neuroprotective response requiring TREM2 signaling.
Evidence labels
review articlesingle-cell RNA-seq
Diseases
- Alzheimer's disease
- Amyotrophic lateral sclerosis
- Multiple sclerosis
Species
mouse, human
Methods
review, single-cell RNA-seq re-analysis
Therapeutic relevance
Established conceptual framework for microglial state targeting across neurodegenerative diseases.
Last reviewed: June 1, 2026