Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

Abstract summary

Parallel GWAS study to Hollingworth et al. 2011 identifying the same AD loci including the MS4A gene cluster. Confirmed that the MS4A locus on chromosome 11q12 contains multiple AD-associated variants. Established CD33 and BIN1 among the strongest non-APOE genetic risk factors for late-onset AD.

Evidence labels

Therapeutic relevance

Provides genetic validation for multiple microglial immune gene targets in AD.