BIN1 regulates BACE1 intracellular trafficking and amyloid-beta production

Abstract summary

Showed that BIN1 (Bridging Integrator 1) interacts with tau and regulates tau spread between neurons. BIN1 expression is highest in microglia and oligodendrocytes. BIN1 knockdown reduces tau propagation in neuronal cultures. BIN1 GWAS variants modulate BIN1 expression levels and are associated with Alzheimer's disease risk.

Evidence labels

Therapeutic relevance

BIN1 modulation may reduce tau propagation; BIN1 is a target for approaches aimed at slowing tau spread in AD.